Bioenergetics‐adverse outcome pathway: Linking organismal and suborganismal energetic endpoints to adverse outcomes
نویسندگان
چکیده
منابع مشابه
Maternal Periodontitis, Preeclampsia and Adverse Pregnancy Outcomes
Background and Aim: Preeclampsia is a considerable problem of pregnancy. Endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. Chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of vascular origin. So this study was carried o...
متن کاملAdverse outcome pathway development II: best practices.
Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through develop...
متن کاملThe thorny path linking cellular senescence to organismal aging.
Half a century is fast approaching since Hayflick and colleagues formally described the limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961). This finding – that normal somatic cells, in contrast to cancer cells, cannot divide indefinitely – challenged the prevailing idea that cells from mortal multicellular organisms were intrinsically ‘immortal’ (Carre...
متن کاملAdverse outcome pathway (AOP) development I: strategies and principles.
An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regula...
متن کاملChemical respiratory allergy: reverse engineering an adverse outcome pathway.
Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and asthma and remains an important occupational health issue. Although less than 80 chemicals have been confirmed as respiratory allergens the adverse health effects can be serious, and in rare instances can be fatal, and there are, in addition, related socioeconomic issues. The challenges that chemical re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Toxicology and Chemistry
سال: 2018
ISSN: 0730-7268,1552-8618
DOI: 10.1002/etc.4280